CT Stress Myocardial Perfusion, Fractional Flow Reserve and Angiography in Patients With Stable Chest Pain Syndromes

Launched by RIGSHOSPITALET, DENMARK · Jan 12, 2021

Keywords

ClinConnect Summary

The DYNAMITE trial is studying how certain advanced heart imaging techniques can help doctors better understand and treat patients with chest pain caused by heart issues. This trial uses a combination of heart scans that look at both the structure of the heart (anatomy) and how well blood is flowing through it (function). The goal is to see if using these techniques can help improve patients' health and reduce serious problems related to heart disease.

To be eligible for the trial, participants should be experiencing chest pain and have either suspected or confirmed heart disease. Specifically, patients who have had heart procedures in the past or are older than 50 with certain risk factors might qualify. Participants will undergo non-invasive heart imaging tests and will be closely monitored throughout the study. It’s important to note that those with ongoing severe chest pain, recent heart attacks, or certain other health conditions may not be able to join. This trial is currently recruiting and aims to find better ways to manage heart health for those experiencing chest pain.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Chest pain in patients with clinically suspected or confirmed ischemic heart disease
• • Clinical indication for non-acute coronary evaluation
• • Status of coronary revascularization
• • 1. With previous coronary revascularization - all patients
• • 2. Without previous coronary revascularization
• • 1. Age≥65 years - all patients with chest pain
• • 2. Age\>50 - \<65 years - typical angina pectoris and at least one cardiovascular risk factor and/or previous myocardial infarction
• • Typical angina requiring all 3 criteria present: a) constrictive discomfort in the front of the chest or in the neck, jaw, shoulder or arm, b) precipitated by physical exertion c) relieved by rest or nitrates within 5 min.
• • Cardiovascular risk factors: hypertension, diabetes, hypercholesterolemia, current smoking, family history of ischemic heart disease, previous stroke, peripheral artery disease
• Exclusion Criteria:
• • Persistent chest pain and signs of ongoing acute myocardial ischemia requiring acute coronary intervention
• • Hospitalization and discharge with the confirmed diagnosis acute coronary syndrome (STEMI or NSTEMI) within the last 6 months
• • Severe valvular heart disease as primary diagnosis and/or in potential need of percutaneous or surgical valve treatment
• • Known severe heart failure (LVEF less than 35%)
• • Language, cultural or mental factors preventing the patient from understanding the informed consent form
• • Known atrial fibrillation
• • Known renal impairment (estimated Glomerular Filtration Rate below \<30 ml/min)
• • Known x-ray contrast allergy
• • Known intolerance to adenosine infusion