Is Clonal Hematopoiesis of Indeterminate Potential Associated With Unprovoked Pulmonary Embolism?

Launched by CENTRE HOSPITALIER UNIVERSITAIRE, AMIENS · Jan 13, 2021

Keywords

ClinConnect Summary

This clinical trial is investigating whether a condition called Clonal Hematopoiesis of Indeterminate Potential (CHIP) is linked to unprovoked pulmonary embolism (a sudden blockage in a lung artery that occurs without an obvious cause). Researchers want to understand if having CHIP, which can be a risk factor for certain blood disorders, is common in patients who have experienced a pulmonary embolism without any clear triggers. By studying this connection, they hope to learn more about the causes of this serious condition.

To participate in the trial, individuals must be between the ages of 65 and 74 and have had a previous unprovoked pulmonary embolism, meaning there isn't a clear reason for the blockage, and they should have tested negative for other blood clotting disorders. Those who have had a previous provoked pulmonary embolism (where a clear cause was identified) may also be eligible. Participants will undergo various assessments related to their health and the study's goals. It’s important to note that individuals over 65 years old or those with active cancer cannot join this trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • For cases : Previous proximal unprovoked pulmonary embolism, negative thrombophilia screening.
• • For control : Previous proximal provoked pulmonary embolism, negative thrombophilia screening.
• Exclusion Criteria:
• • Age superior to 65 years old,
• • Active cancer