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Search / Trial NCT04715984

Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

Launched by VANDERBILT UNIVERSITY MEDICAL CENTER · Jan 14, 2021

Trial Information

Current as of September 29, 2025

Recruiting

Keywords

Deep Brain Stimulation

ClinConnect Summary

This clinical trial is focused on understanding how certain areas of the brain contribute to cognitive problems in people with Parkinson's disease. Researchers want to learn more about the brain's activity during deep brain stimulation surgery, which is a treatment for Parkinson's. By observing the brain's activity in these specific areas, called corticostriatal structures, they hope to gain insights into the non-motor symptoms, like memory and thinking difficulties, that some patients experience.

To participate in this study, individuals must be scheduled for deep brain stimulation surgery at Vanderbilt University Medical Center and be at least 40 years old with a diagnosis of Parkinson's disease. Participants will need to be able to follow instructions during the surgery. If eligible, they can expect to have their brain activity recorded during the procedure, which will help researchers understand more about cognitive impairment in Parkinson's. This study is currently recruiting participants, and it aims to improve knowledge about how Parkinson's affects thinking and memory.

Gender

ALL

Eligibility criteria

  • Inclusion criteria:
  • Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center
  • Planned clinical electrode trajectory that contacts caudate
  • Age greater than or equal to 40
  • Diagnosis of Parkinson's disease
  • Able to participate in intraoperative testing
  • English speaking
  • Exclusion criteria:
  • Age less than 40
  • Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)
  • Movement disorder other than Parkinson's disease

About Vanderbilt University Medical Center

Vanderbilt University Medical Center (VUMC) is a leading academic medical center located in Nashville, Tennessee, renowned for its commitment to advancing healthcare through innovative research and clinical excellence. As a prominent sponsor of clinical trials, VUMC integrates cutting-edge scientific inquiry with patient-centered care, supporting a diverse array of studies aimed at enhancing medical knowledge and improving treatment outcomes. With a robust infrastructure and a multidisciplinary team of experts, VUMC fosters collaboration across various fields, ensuring the highest standards of safety and ethical considerations in its research endeavors. Through its dedication to medical discovery and education, VUMC plays a pivotal role in shaping the future of medicine.

Locations

Nashville, Tennessee, United States

Patients applied

0 patients applied

Trial Officials

Sarah Bick, MD

Principal Investigator

Vanderbilt University Medical Center

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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