Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment
Launched by VANDERBILT UNIVERSITY MEDICAL CENTER · Jan 14, 2021
Trial Information
Current as of October 21, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is focused on understanding how certain areas of the brain contribute to cognitive problems in people with Parkinson's disease. Researchers want to learn more about the brain's activity during deep brain stimulation surgery, which is a treatment for Parkinson's. By observing the brain's activity in these specific areas, called corticostriatal structures, they hope to gain insights into the non-motor symptoms, like memory and thinking difficulties, that some patients experience.
To participate in this study, individuals must be scheduled for deep brain stimulation surgery at Vanderbilt University Medical Center and be at least 40 years old with a diagnosis of Parkinson's disease. Participants will need to be able to follow instructions during the surgery. If eligible, they can expect to have their brain activity recorded during the procedure, which will help researchers understand more about cognitive impairment in Parkinson's. This study is currently recruiting participants, and it aims to improve knowledge about how Parkinson's affects thinking and memory.
Gender
ALL
Eligibility criteria
- Inclusion criteria:
- • Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center
- • Planned clinical electrode trajectory that contacts caudate
- • Age greater than or equal to 40
- • Diagnosis of Parkinson's disease
- • Able to participate in intraoperative testing
- • English speaking
- Exclusion criteria:
- • Age less than 40
- • Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)
- • Movement disorder other than Parkinson's disease
About Vanderbilt University Medical Center
Vanderbilt University Medical Center (VUMC) is a leading academic medical center located in Nashville, Tennessee, renowned for its commitment to advancing healthcare through innovative research and clinical excellence. As a prominent sponsor of clinical trials, VUMC integrates cutting-edge scientific inquiry with patient-centered care, supporting a diverse array of studies aimed at enhancing medical knowledge and improving treatment outcomes. With a robust infrastructure and a multidisciplinary team of experts, VUMC fosters collaboration across various fields, ensuring the highest standards of safety and ethical considerations in its research endeavors. Through its dedication to medical discovery and education, VUMC plays a pivotal role in shaping the future of medicine.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Nashville, Tennessee, United States
Patients applied
Trial Officials
Sarah Bick, MD
Principal Investigator
Vanderbilt University Medical Center
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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