COLO-DETECT: Can an Artificial Intelligence Device Increase Detection of Polyps During Colonoscopy?

Launched by SOUTH TYNESIDE AND SUNDERLAND NHS FOUNDATION TRUST · Jan 20, 2021

Keywords

ClinConnect Summary

Colorectal cancer is common, affecting 1 in 15 men and 1 in 18 women in the UK in their lifetime. Many colorectal cancers develop from polyps via the adenoma-carcinoma sequence: there is a pre-cancerous stage (adenoma) during which it is possible to remove the polyp and therefore prevent it from progressing to colorectal cancer. The gold standard tool for doing this is colonoscopy. However, colonoscopy does not pick up all polyps, particularly flat polyps.

Missed polyps can result in colorectal cancer, so it is imperative to detect and remove as many polyps as possible. Many different inte...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Able to give informed consent
• • Patients attending for colonoscopy
• • Through standard National Health Service (NHS) care (most commonly due to iron deficiency anaemia, altered bowel habit, weight loss, rectal bleeding, positive FIT (faecal immunohistochemical test) based on symptoms, those referred on basis of family history, abnormal cross- sectional imaging, polyp surveillance or post CRC surveillance)
• • Through Bowel Cancer Screening Programme (FIT positive, surveillance)
• • Colonoscopy to be performed by colonoscopist trained to perform GGC as part of the study
• Exclusion Criteria:
• • Absolute contraindications to colonoscopy
• • Patients lacking capacity to give informed consent
• • Confirmed or expected pregnancy
• • Established or suspected large bowel obstruction or pseudo-obstruction
• • Known presence of colorectal cancer or polyposis syndromes
• • Known colonic strictures (meaning that the colonoscopy maybe incomplete)
• • Known active colitis (ulcerative colitis, Crohn's colitis, diverticulitis, infective colitis)
• • Inflammatory Bowel Disease (IBD) surveillance procedures
• • Patients who are on clopidogrel, warfarin, or other antiplatelet agents or anticoagulants who have not stopped this for the procedure (as polyps cannot be removed and thus histology cannot be confirmed)
• • Patients who are attending for a planned therapeutic procedure or assessment of a known lesion
• • Patients referred with polyps identified on Bowel Scope procedure