CHronic Nonbacterial Osteomyelitis International Registry

Launched by SEATTLE CHILDREN'S HOSPITAL · Jan 22, 2021

Keywords

ClinConnect Summary

The CHronic Nonbacterial Osteomyelitis International Registry is a research study that aims to better understand a condition called chronic recurrent multifocal osteomyelitis (CRMO) or chronic nonbacterial osteomyelitis (CNO). This study is looking at how the disease progresses over time and how different treatments affect patients. It will collect data for about 10 years to learn more about the experiences of people with this condition.

To participate in this study, you need to be 21 years old or younger and have certain signs of the disease, such as bone swelling seen on specific MRI scans. Additionally, you will need to have imaging tests done to check for the disease. However, if you have a history of cancer or current bone infections, you won’t be eligible to join. If you do participate, you can expect to provide information about your health and treatments over the years, helping researchers gather valuable insights to improve care for others with this condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • - Age at enrollment is equal to or younger than 21 years of age
• • Presence of bone edema on STIR or T2 fat saturation sequence on MRI within 12 weeks of enrollment
• • Whole body imaging evaluation (either WB MRI or bone scintigraphy)
• • Bone biopsy to exclude infection or malignancy unless bone lesions follow typical distribution or there is IBD, psoriasis, or palmar plantar pustulosis
• Exclusion Criteria:
• • - History of or current malignancy
• • Current infectious osteomyelitis
• • Contraindication to the selected treatment agent