Comparative Analgesic Effects of Paracetamol/Codeine and Ibuprofen on Pain After Third Molar Surgery

Launched by UNIVERSITY OF ROMA LA SAPIENZA · Jan 25, 2021

Keywords

ClinConnect Summary

Materials and methods: One hundred twenty healthy outpatients aged 15 to 29 years undergoing surgical removal of one bony impacted mandibular third molar were enrolled in this, single-center, prospective, randomized, triple-blind parallel-group, placebo-controlled, clinical trial. Study participants were randomly assigned to three treatment arms. According to the concealed allocation, each patient 30 minutes before surgery received paracetamol 500 mg plus codeine 30 mg (group A), ibuprofen 400 mg (group B) or placebo (group C). Rescue therapy allowed in the postoperative period was paraceta...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • healthy status (ASA class I);
• • nonsmoker;
• • not pregnant or breastfeeding;
• • no medication consumption in the past 21 days;
• • good oral hygiene;
• • bony impaction of one mandibular third molars;
• • the presence of the first and second molars;
• • compliance to cooperate with the research protocol.
• Exclusion Criteria:
• • chronic systemic disease;
• • medications with potential interaction to paracetamol-codeine or ibuprofen;
• • a history of intolerance or hypersensitivity to the study drugs;
• • any pre-existing pain and acute inflammatory or infectious conditions; - inability to understand or perform the study procedure.