Video-oculography and Parkinson's Disease

Launched by ASSOCIATION DE RECHERCHE BIBLIOGRAPHIQUE POUR LES NEUROSCIENCES · Jan 28, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how eye movements, known as oculomotricity, change over time in people with mild to moderate Parkinson's disease. The researchers want to understand how these eye movement changes relate to other health assessments, including motor skills and thinking abilities, over a period of seven years. They are also looking at how Parkinson's medications might affect these eye movements and whether tracking them can help monitor the progression of the disease.

To participate, you must be between 65 and 74 years old, diagnosed with idiopathic Parkinson's disease, and have certain brain scans that confirm the diagnosis. You should be able to understand and communicate in French and have a caregiver present. Participants will undergo evaluations of their eye movements and other neurological assessments throughout the study. It's important to note that candidates with significant psychiatric or other neurological conditions may not be eligible. If you decide to join, you'll be contributing valuable information that could help improve understanding and treatment of Parkinson's disease.

Gender

ALL

Eligibility criteria

• \*Inclusion Criteria:
• • 1. Male or Female;
• • 2. Clinically defined idiopathic Parkinson's Disease (PD);
• • 3. Brain MRI performed in routine care in the 12 months preceding inclusion;
• • 4. Cerebral DaTSCAN or cerebral PET with F-DOPA, performed as routine care before inclusion (no time limit), confirming presynaptic dopaminergic denervation;
• • 5. Hoehn \& Yahr score: 1 to 3;
• • 6. Normal clinical examination of oculomotricity (slight impairment of smooth pursuit accepted);
• • 7. Neuro-cognitive disorders: absent or minor (according to DSM5);
• • 8. Sufficient written and oral expression in French;
• • 9. Covered by a health insurance system;
• • 10. Written informed consent signed by the patient;
• • 11. Presence of a caregiver.
• \* Exclusion Criteria:
• • 12. Psychiatric comorbidity (except anxiety or mild to moderate depression);
• • 13. Neurological comorbidity, if significant;
• 14. Brain MRI showing:
• • 1. significant cerebrovascular pathology (Fazekas I admitted),
• • 2. another brain disease, including stroke.
• • 15. Major cognitive impairment;
• 16. Absolute exclusion criteria and "Red flags" of the 2015 criteria orienting towards another degenerative pathology of the extrapyramidal system:
• • Cerebellar syndrome
• • Vertical oculomotricity disorders on clinical examination
• • Motor symptoms restricted to the lower limbs
• • Bilateral and perfectly symmetrical parkinsonism
• • Early dystonia
• • Clinical profile suggestive of behavioral variant frontotemporal dementia (bvFTD)
• • Progressive aphasia or apraxia
• • Moderate or severe postural instability and / or early falls
• • Early bulbar dysfunction (dysarthria, swallowing disorders)
• • Ventilatory dysfunction (inspiration)
• • Severe dysautonomia
• • DOPA-resistance
• • Neuroleptic treatment or related
• • 17. Normal MIBG myocardial scintigraphy (if performed).