Pre- Vs Postoperative Thromboprophylaxis for Liver Resection

Launched by HELSINKI UNIVERSITY CENTRAL HOSPITAL · Jan 26, 2021

Keywords

ClinConnect Summary

This clinical trial is studying the best timing for starting blood clot prevention (called thromboprophylaxis) in patients undergoing liver surgery for cancer. Doctors can start this prevention either before the surgery (preoperative) or after the surgery (postoperative). There is currently no clear agreement on which method is better, and existing guidelines are based on limited evidence. This trial aims to compare these two approaches to see which one works best in reducing the risk of blood clots without increasing the risk of bleeding.

To be eligible for this trial, participants should be adults aged 18 and older who are scheduled for liver resection surgery. However, those who are on certain blood-thinning medications or need emergency surgery won’t be able to participate. If you join the trial, you will be randomly assigned to either start blood clot prevention before or after your surgery. Throughout the study, doctors will monitor your health to gather important information about the safety and effectiveness of these two timing strategies. This research could help improve care for patients undergoing liver surgery in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All patients undergoing liver resection
• Exclusion Criteria:
• • Patient on anticoagulative medication (heparin, low-molecular weight heparin, warfarin, direct oral anticoagulants) during last month pre-surgery
• • Emergency operation (e.g. for trauma or infection)
• • Age \< 18 years
• • Allergy or other contraindication to planned low-molecular weight heparin
• • Inability to give written informed consent
• • Liver resection not performed (removed from analyses after randomization)