Efficacy of Lidocaine and Xylometazoline Intranasal Spray in Anesthetizing Maxillary Teeth

Launched by DOW UNIVERSITY OF HEALTH SCIENCES · Jan 26, 2021

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ClinConnect Summary

Different anesthetic techniques are used for achieving pulpal anesthesia of maxillary teeth. The most commonly used technique is the infiltration anesthesia that currently is the gold standard. However, infiltration uses a dental needle that is associated with its de merits also. This led to the discovery of novel methods to anesthetize teeth with smaller diameter needles or computerized delivery of local anesthesia. Recently tetracaine and oxymetazoline were used as local anesthetic agents in the form of an intranasal spray to achieve pulpal anesthesia of maxillary teeth. However tetracain...

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Eligibility criteria

• • INCLUSION CRITERIA
• • Adults aged 18-40 years,
• • Patients having a vital maxillary premolar, canine or incisor.
• • Patients having Class 1,2,3,4 or 5 restorations (G.V. Black).95
• • Patients having heart rate between 55 and 100 beats per min.
• • Patients with a seated Systolic blood pressure between 95 and 150 mm Hg and diastolic blood pressure between 60 and 100 mm of Hg. (Although short-term use of topical alpha-2 agonists like xylometazoline has no systemic toxicity and are available as over the counter drugs but long-term abuse has been reported to cause systemic vasoconstriction and cardiovascular complications like hypertensive crisis therefore the cut off limit has been selected for blood pressure).
• • Teeth with no radiographic evidence of pulpal or periapical pathosis.
• • Patients having ICDAS caries detection score of 4, 5 or 6.
• • Patients who fulfilled alcohol sniff test criterion.
• • EXCLUSION CRITERIA
• • Patients with Upper respiratory tract infection.
• • Patients with Uncontrolled thyroid disease.
• • Patients having a known allergy to any of the components used in the solution.
• • Pregnant or breast feeding patients.
• • Those patients having 5 or more nosebleeds per month.
• • Patients who received any local anesthetic/analgesic within 24 hours of study drug administration.