The Impact of Overnight Nutrition Support on Sleep and Circadian Rhythm Disruption in the ICU

Launched by MASSACHUSETTS GENERAL HOSPITAL · Feb 1, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how changing the timing of nutrition support for patients in the cardiac surgical ICU can impact their sleep and overall health. Specifically, the researchers want to see if providing nutrition during the day instead of overnight helps improve sleep quality, maintain natural body rhythms (called circadian rhythms), and reduce inflammation and other health issues related to metabolism.

To participate in the study, you need to be an adult (18 years or older) who is scheduled for heart surgery and will stay in the ICU for more than 48 hours after the operation. Unfortunately, people with certain health conditions, such as severe liver or kidney problems, or those who cannot eat through a feeding tube, cannot join. If you decide to participate, you will follow specific procedures, and the team will monitor how the new feeding schedule affects your recovery and well-being. This trial is currently looking for volunteers, so if you’re interested or have questions, feel free to ask your healthcare provider.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult male or non-pregnant female volunteers (age 18+)
• • Scheduled for a cardiac surgical procedure with planned post-operative admission to the ICU for \>48 hours
• • Able and willing to give consent and comply with study procedures
• Exclusion Criteria:
• • Blind, deaf or unable to speak English
• • Women who are pregnant or nursing
• • Contraindications to safe use enteral nutrition, including gastrointestinal obstruction
• • Personal history of intestinal malabsorption, gallbladder disease or pancreatitis
• • Dietary restrictions precluding enteral feeds
• • Renal and liver failure requiring dialysis or Child-Pugh score \> 7
• • Severe deficit due to structural or anoxic brain damage
• • With skin condition that precludes wearing sensors