Food and Circadian Timing

Launched by OREGON HEALTH AND SCIENCE UNIVERSITY · Feb 5, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how a high-fat diet affects our body's internal clock, known as the circadian timing system. Over a period of 46 days, participants will take part in both outpatient and inpatient visits to help researchers understand how quickly our bodies adjust to changes in diet. The trial is currently seeking healthy, lean men and women aged 65 to 74 who do not have any major dietary restrictions or underlying health conditions like diabetes or heart disease.

If you choose to participate, you will be monitored closely during the study and will follow specific dietary guidelines. It’s important to know that individuals who have a history of working night shifts, consuming a high-fat diet regularly, or have certain health issues will not be eligible for this study. By participating, you will help advance our understanding of how diet influences our natural body rhythms, which can lead to better health recommendations for everyone.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy, lean men and women
• Exclusion Criteria:
• • Major dietary restrictions (such as entirely dairy-free and/or meat-free diets)
• • A body mass index (BMI) of 18.5\< \[BMI\] \< 24.9 kg/m\^2 and a waist circumference \<94/80cm
• • Currently psychiatrically/psychologically unsuitable for participation
• • Drug/alcohol use, including smoking
• • Medication/drug use, including prescribed and over-the-counter medications
• • History of working irregular day and night hours, regular night work, or rotating shift work for the 1 year prior to the study.
• • Traveled across more than 1 time zone during the 3 months prior to the study
• • Currently consuming a habitual high-fat diet
• • Chronobiologic and sleep disorders
• • Diseases of the Cardiovascular System
• * Metabolic Syndrome; Two or more of these factors will be excluded from the study:
• • 1. HDL cholesterol of less than 40 mg/dL in men or less than 50 mg/dL in women;
• • 2. systolic blood pressure\>135 mmHg or diastolic blood pressure\>85 mmHg;
• • 3. Fasting blood glucose ≥ 100 mg/dL;
• • 4. Triglycerides ≥ 150 mg/dL.
• • Pre-Diabetes/Diabetes
• • Hypertension
• • Disorders of the Respiratory System
• • Disorders of the Kidney and Urinary Tract
• • Infectious Diseases
• • Disorders of the Gastrointestinal System
• • Disorders of the Immune System
• • Disorders of the Hematopoietic System
• • Neoplastic Diseases
• • Endocrine and Metabolic Diseases
• • Neurologic Disorders
• • Subjects must not be currently participating in another research study that would influence their safe participation in our study