HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial

Launched by POPULATION HEALTH RESEARCH INSTITUTE · Feb 3, 2021

Keywords

ClinConnect Summary

The HIP ATTACK-2 trial is a study designed to see if having surgery sooner for hip fractures in patients who also have heart problems (specifically, an increase in heart injury markers) can help them live longer and healthier after 90 days. The trial will compare this faster surgery approach to the usual care patients receive and will look at several important factors, such as whether patients can walk independently, how quickly they can start moving after surgery, and their overall health and quality of life during this time.

To participate in this trial, you need to be at least 45 years old and have a hip fracture that needs surgery, along with elevated heart injury markers. However, certain conditions, like being on certain blood thinners or having more severe heart issues, may prevent you from joining. If you do take part, you will be closely monitored for 90 days to track your recovery and any complications, giving you a chance to contribute to important research that could improve care for future patients with similar conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. age ≥45 years;
• • 2. diagnosis of hip fracture during working hours with a low-energy mechanism requiring surgery;
• • 3. troponin elevation ( at least one troponin measurement above the upper limit of normal occurring from the time of hip fracture to the time of randomization); and
• • 4. informed consent.
• Exclusion Criteria:
• • 1. taking a therapeutic dose of an anticoagulant for which no reversing agent is available and the anesthesiologist or surgeon believe surgery within 6 hours of eligibility criteria met would not be safe;
• • 2. patients on a therapeutic vitamin K antagonist with a history of heparin induced thrombocytopenia (HIT);
• • 3. patients with peri-prosthetic fracture, open fracture or bilateral fractures;
• • 4. patients requiring an emergency surgery for another reason (e.g., subdural hematoma);
• • 5. patients with acute myocardial infarction deemed to be clinically unstable, with a mechanical complication (i.e., acute papillary muscle rupture, ventricular septal defect), ST elevation myocardial infarction, or cardiogenic shock;
• • 6. patients refusing consent; or
• • 7. patients previously enrolled in HIP ATTACK-2.