Identification of Circulating microRNAs in Adolescent Idiopathic Scoliosis

Launched by ISTITUTO ORTOPEDICO RIZZOLI · Feb 8, 2021

Keywords

ClinConnect Summary

This clinical trial is studying a condition called Adolescent Idiopathic Scoliosis (AIS), which is a type of curvature of the spine that occurs in teenagers for reasons that are not fully understood. The researchers want to identify certain tiny molecules called microRNAs in the blood of patients with AIS. These microRNAs are known to be involved in bone and tissue health, and the goal is to see if they can help understand the disease better and possibly guide future diagnosis and treatment.

To participate in the study, you must be between 11 and 17 years old and have been diagnosed with idiopathic scoliosis, meaning your spine has a significant curve (more than 10 degrees) without any known cause. You should also have medical records and imaging tests available from the last two years. Healthy teens in the same age range can also join as a comparison group. Participants will not need to undergo any surgery related to the study, and they will help researchers gather important information that may lead to new ways to diagnose and understand AIS in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Cases:
• • Age between 11-17 years
• • Diagnosis of idiopathic scoliosis with a Cobb angle\> 10 °
• • Minimum follow-up of two years
• • Clinical data and radiological tests available and no surgical treatment prior to enrollment in the study
• Controls:
• • Age between 11-17 years
• • Healthy subjects not affected by orthopedic and oncological diseases
• Exclusion Criteria:
• • Severe cognitive impairment or psychiatric disorders
• • Patients with scoliosis due to secondary causes
• • Women of childbearing age must not be pregnant