Coronary Computed Tomographic Angiography in Intermediate-risk Chest Pain Patients

Launched by KAROLINSKA INSTITUTET · Feb 7, 2021

Keywords

ClinConnect Summary

This clinical trial is looking at whether using a special imaging test called coronary computed tomographic angiography (CTA) early on can help people who come to the Emergency Department with chest pain and are at moderate risk for heart issues. The goal is to see if this test can reduce the chances of serious outcomes like death or needing to go back to the hospital for heart problems.

To participate in the trial, you need to be at least 18 years old and have visited the Emergency Department within the last 24 hours with chest pain or similar symptoms. The doctors will also check your HEART score, which helps assess your risk for heart disease. If you meet these criteria and decide to join, you'll undergo the CTA test, and the research team will monitor your health over time. It’s important to know that certain conditions, like serious allergies or other heart problems, may exclude you from participating.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age≥18 years.
• • 2. Within 24 hours from presenting to the ED with chest pain or other symptoms suggestive of coronary artery disease (CAD)
• • 3. HEART-score \>3 (according to http://www.heartscore.nl/)
• • 4. Written informed consent obtained
• Exclusion Criteria:
• • 1. Any condition that may influence the patient's ability to comply with study protocol.
• • 2. Acute MI
• • 3. Known obstructive CAD (\>50%) or previous PCI or CABG.
• • 4. Clear alternative diagnosis
• • 5. Estimated glomerular filtration rate (eGFR) \< 30 ml/min/1.73m2
• • 6. Major allergy to iodinated contrast media
• • 7. Circumstances making high quality images unlikely.
• • 8. Not a Swedish resident with a personal ID-number.
• • 9. Pregnancy or breast feeding
• • 10. Further investigation for CAD not indicated, due to limited life expectancy, quality of life or functional status
• • 11. Previous inclusion in the trial