Management of Shock in Children With SAM or Severe Underweight and Diarrhea

Launched by INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH, BANGLADESH · Feb 7, 2021

Keywords

ClinConnect Summary

This clinical trial aims to find out the best way to treat severely malnourished children who are experiencing shock due to dehydration and diarrhea. Diarrhea is a major cause of death in young children, especially those with severe acute malnutrition (SAM). In this study, researchers will compare two different approaches: giving medications that help improve blood flow and pressure, or performing blood transfusions, for children who do not respond to standard fluid treatments recommended by the World Health Organization (WHO).

To be eligible for the trial, children aged 1 to 59 months with acute malnutrition and diarrhea can participate, including those with conditions like cerebral palsy or Down syndrome. Caregivers must provide consent for their child to take part. If a child is very sick or needs immediate emergency care, they won't be included. Families who join the study can expect to receive specialized care while helping researchers learn more about the best treatments for these vulnerable children.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Children of either sex with acute malnutrition and diarrhea
• • 2. Age: 1-59 months
• • 3. Children with cerebral palsy (CP) and/or developmental delay, Down Syndrome with or without heart diseases
• • 4. Fluid refractory shock
• • 5. Consent from the caregivers/parents
• Exclusion Criteria:
• • 1. Having a rare blood group (Rh negative blood groups provided that donor is not available)
• • 2. A child requiring cardio-pulmonary resuscitation during screening or having gasping respiration