Perioperative Inflammatory Response Assessment in High-risk Patients Undergoing Noncardiac Surgery

Launched by MEDICAL UNIVERSITY OF VIENNA · Feb 10, 2021

Keywords

ClinConnect Summary

This clinical trial is investigating the connection between inflammation and heart problems that can occur after noncardiac surgery, particularly in high-risk patients. Researchers want to find out if higher levels of inflammation, measured by a blood test for a substance called C-reactive protein, are linked to serious heart complications after surgery. They will also look at how inflammation might affect kidney health and how many days patients spend at home after their surgery.

To participate in this study, patients need to be at least 45 years old and have surgery planned for more than two hours. They also need to meet at least one of several health criteria, such as having a history of heart disease or high blood pressure, or being a certain age (75 or older). Participants will provide informed consent and will be monitored for their heart and kidney health during their recovery. This trial aims to help doctors understand how inflammation affects recovery and could lead to better care for patients facing surgery.

Gender

ALL

Eligibility criteria

• All patients need to meet all of the following criteria for inclusion (1-4):
• • 1. Surgery planned for more than two hours
• • 2. ≥ 45 years of age
• • 3. Provide written informed consent AND
• • 4. Fulfill ≥ 1 of the following criteria (A-K)
• Inclusion Criteria:
• • NT-proBNP ≥ 200 ng/L
• • Troponin T \> 25 ng/L
• • History of coronary artery disease
• • History of peripheral artery disease (PAD)
• • 75 years or older
• • History of transient ischemic attack (TIA) or stroke
• • Current smoking or cessation of smoking within 2 years
• • Diabetes or currently taking anti-diabetic drug
• • Hyperlipidemia
• • History of hypertension or currently taking an antihypertensive drug
• • Atrial fibrillation
• Exclusion Criteria:
• • Patients on immune-suppressive therapy
• • ICU patients undergoing surgery
• • Preoperative Sepsis/systemic inflammatory syndrome (SIRS) needing ICU treatment
• • Preoperative hemodynamically instable patients, who require vasopressor or inotropic support
• • History of severe heart failure (defined as left ventricular ejection fraction (LVEF) \< 30%)
• • Liver cirrhosis
• • Chronic inflammatory bowel diseases (CIBD)
• • Severe rheumatic diseases requiring immunosuppressive treatment