Multidimensional Apathy in Psychiatric Pathologies.

Launched by UNIVERSITY HOSPITAL, STRASBOURG, FRANCE · Feb 11, 2021

Keywords

ClinConnect Summary

This clinical trial is focused on understanding a condition called apathy, which is when people show less motivation or interest in activities they once enjoyed. Apathy is common in individuals with mental health issues like schizophrenia and depression, affecting their daily lives and relationships. The study aims to explore the different types of cognitive and brain functions related to apathy, dividing it into three categories: difficulties with planning and decision-making, emotional disconnection, and lack of initiative. By identifying these different forms, researchers hope to better understand what causes apathy and how it can be treated in the future.

To participate in the study, you need to be between 18 and 60 years old and either a man or a woman, whether you are in a hospital or not. You should also be covered by health insurance and able to give informed consent, which means you understand what the study involves. People with schizophrenia or depression who meet specific diagnostic criteria can take part, but those with certain medical conditions or who are pregnant cannot. Participants can expect to engage in assessments that will help researchers learn more about the cognitive aspects of apathy, contributing to future treatment options for this challenging symptom.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Inclusion criteria (all subjects):
• • age between 18 and 60 years
• • men or women volunteers, hospitalized or not
• • subject affiliated to an health insurance
• • subject having signed an informed consent
• Inclusion criteria (for schizophrenic patients):
• • - presence of DSM-V TR criteria for schizophrenia (American Psychiatric Association, 1994)
• Inclusion criteria (for depressive patients):
• • - presence of DSM-V TR criteria for depression (American Psychiatric Association, 1994)
• Exclusion Criteria:
• • a major or non stabilized somatic disorder
• • medical history likely to affect cerebral anatomy or linked to an abnormality (neonatal distress, neurochirurgical intervention, neurological disorders, stroke attack)
• • any disorders involved in the use of a psycho-active substance (as defined by the DSM-IV)
• • sensory disabling impairments, and specifically visual acuity \< 8
• • general anaesthesia during the 3 months before the study
• • pregnancy (declared by the subject)
• • persons in an emergency situation
• • persons deprived in any way of their liberty
• • persons in period of exclusion in an other protocol
• Exclusion criteria (for controls):
• • - use of psychotropic substance during the 3 weeks before the study
• Exclusion criteria (for patients):
• • - use of benzodiazepines