Stop Ovarian Cancer Young; Effect of the Opportunistic Salpingectomy on Age of Menopause

Launched by RADBOUD UNIVERSITY MEDICAL CENTER · Feb 16, 2021

Keywords

ClinConnect Summary

This is a long-term, observational study in the Netherlands called Stop Ovarian Cancer Young (STOPOVCAyoung). Researchers are following up to about 1,200 premenopausal women for up to 15 years to see whether removing the fallopian tubes during sterilization (opportunistic salpingectomy) affects the age at natural menopause (the time when periods stop). The main outcome is menopause age, and researchers will also look at whether women have any regret about their sterilization choice, measured about 1 year after surgery and again around menopause. This study does not test a new drug or treatment.

Who can join and what to expect: Women aged 30–45 who are premenopausal and planning sterilization can be part of the study. The intervention group consists of those having opportunistic salpingectomy (fallopian tube removal) as their sterilization method. The control group includes women choosing other sterilization methods (such as tubal ligation) or no sterilization, matched by age. Participants must understand Dutch and consent to surveys. Exclusions include being postmenopausal, being younger than 30 or older than 45, having had prior salpingectomy or oophorectomy or hysterectomy, certain genetic conditions or prior cancer treatment, and language or consent limitations. The study is conducted at sites in the Netherlands (including Eindhoven) and led by Radboud University Medical Center. Results are not available yet.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Intervention group
• • Undergoing an Opportunistic Salpingectomy as sterilization method
• • Premenopausal status at enrolment
• • Age between 30 and 45 years
• • Will have residual ovarian tissue after surgery
• • Able to understand the written or spoken Dutch language
• • Gives consent for participating in surveys
• • Control group
• • Premenopausal status at enrolment
• • Either sterilization by tubal ligation or no sterilization at all
• • Age between 35 and 45 years
• • Able to understand the written or spoken Dutch language
• • Gives consent for participating in surveys
• Exclusion Criteria:
• • Postmenopausal status at enrolment
• • Under the age of 35 or above 45
• • Previous salpingectomy of oophorectomy
• • Previous hysterectomy
• • Women with abnormal karyotype (such as Turner Syndrome and Fragile X syndrome)
• • Underwent chemotherapy or radiation
• • Unable to understand the written or spoken Dutch language