Amyloid Proteins From Medullary Thyroid Cancer and Laryngeal Amyloidosis

Launched by THE LEEDS TEACHING HOSPITALS NHS TRUST · Feb 15, 2021

Keywords

ClinConnect Summary

This clinical trial is exploring the structures of amyloid proteins found in tumors from patients with Medullary Thyroid Cancer (MTC) and Laryngeal Amyloidosis (LA). Amyloid proteins can build up in the brain and are linked to serious conditions like Alzheimer's disease and dementia. By comparing amyloid from tumor samples with those made in the lab, researchers hope to understand how genetic changes and other factors influence the formation of these proteins. This knowledge could help in creating new treatments for neurodegenerative diseases.

To participate in this study, individuals must be at least 18 years old and diagnosed with either MTC or LA. They need to be able to give consent for surgery and agree to undergo a specific surgical procedure to collect tumor samples. Those who do not have a diagnosis of MTC or LA, are under 18, or are not recommended for surgery will not be eligible. Participants can expect to contribute to important research that could lead to better ways to treat conditions involving amyloid buildup in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosed with known or suspected MTC or LA
• • Age \>= 18 years, no upper age limit
• • Able to provide informed consent for both surgical treatment and inclusion into this study
• • For MTC patients, treatment recommendation from the Thyroid MDT is for either hemithyroidectomy or total thyroidectomy
• • for LA patients, agreement with their attending clinician to undergo surgical debulking of disease under general anaesthetic. The procedure is called 'microlaryngoscopy and biopsy/debulking'
• Exclusion Criteria:
• • No known or suspected diagnosis of MTC or LA
• • Age \<18 years
• • Unable to provide informed consent
• • Treatment recommendation from Thyroid MDT is for any treatment excluding primary surgery (ie palliation, best supportive care, chemotherapy, radiotherapy etc)
• • For LA patients, no agreement between patient and attending clinician to proceed with surgery as primary treatment.