Bradykinin-degradating Enzymes Activities in Angiotensin-Converting Enzyme Inhibitors-associated Angioedema

Launched by UNIVERSITY HOSPITAL, GRENOBLE · Feb 16, 2021

Keywords

ClinConnect Summary

This clinical trial is studying a specific type of swelling called angioedema that can occur in some people who take Angiotensin-Converting Enzyme (ACE) inhibitors, which are medications often used to treat high blood pressure. The trial aims to understand why some patients experience a return of this swelling even after stopping the medication. Researchers believe that this may be related to a decrease in certain enzymes in the body that help break down a substance called bradykinin, which can cause swelling.

To participate in the trial, individuals need to be at least 18 years old and have experienced angioedema related to ACE inhibitors for less than 15 days or have had a significant episode lasting at least 15 hours. They must also agree to participate by signing a consent form and be covered by social security. The trial is currently recruiting participants and aims to gather important information that could help predict and manage future episodes of angioedema in patients. Those who join will be part of a study that seeks to improve understanding and treatment options for this condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Men and women at least 18 years old
• • Presenting AE secondary to treatment with Angiotensin Conversion Enzyme Inhibitors for less than 15 days, or an isolated AE (without superficial hives), which lasts at least 15 hours, and whose diagnosis is validated by the expert committee,
• • Having signed informed and written consent
• • And being affiliated with social security
• Exclusion Criteria:
• • Patient who had one or more AEs prior to IEC
• • Hereditary or acquired deficiency of C1 inhibitor
• • Subject with known mutation of the F12 or PLG gene Subject in times of exclusion from another research involving the human person type 1 or 2 Persons referred to in sections L1121-5 to L1121-8 of the public health code (pregnant woman, breastfeeding mother, person deprived of liberty, person subject to legal protection) subject that cannot be contacted in an emergency situation