Improving Care After Inherited Cancer Testing

Launched by VANDERBILT-INGRAM CANCER CENTER · Feb 18, 2021

Keywords

ClinConnect Summary

The IMPACT Study is designed to improve how people manage their cancer risks and communicate important genetic test results to their families. Specifically, it focuses on individuals who have a known genetic change linked to an inherited cancer syndrome, such as those related to prostate, colorectal, endometrial, or breast cancer. The study aims to test different ways to help participants and their families understand and follow the recommended cancer screenings and preventive measures based on their genetic information.

To be eligible for this study, participants should be at least 18 years old, speak English, and have access to the internet. They must not have been adopted, meaning they should know about their biological family history. Participants should have either a documented genetic variant that is known to increase cancer risk or a variant of uncertain significance. Those who join the study can expect to receive support in discussing their genetic test results with their family members, ensuring that everyone understands their risk and necessary steps for health management. This trial is currently looking for participants, so if you meet the criteria and are interested, consider getting involved!

Gender

ALL

Eligibility criteria

• • Randomized Controlled Trial Eligibility: All trial participants will be autonomous adults who are capable of participating in the study
• Inclusion Criteria:
• • English-speaking men and women aged 18 years or older
• • Not adopted (i.e., have information about their biological relatives)
• • Have access to internet and a computer, tablet, or smartphone
• • Documented pathogenic/likely pathogenic variant in an inherited cancer gene that has CRM guidelines listed in the National Comprehensive Cancer Network (NCCN) Genetic/Familial Panel focused on Breast, Ovarian, and Pancreatic or Colorectal cancers
• * Must meet at least one of the following criteria:
• * Intervention A (GeneSHARE) criteria: Have at least one at-risk adult, living relative who either:
• • has not been told about the genetic test result by the participant
• • has not had their own genetic testing
• • Intervention B (LivingLabReport) criteria: Are non-adherent (i.e., either undertreatment or overtreatment) to at least one of the current NCCN CRM guidelines or if currently adherent, require ongoing cancer screening
• VUS Pilot Study Eligibility: All VUS pilot study participants will be autonomous adults who are capable of participating in the study. Eligibility criteria include:
• • English-speaking men and women aged 18 years or older
• • Not adopted (i.e., have information about their biological relatives)
• • Have access to internet and a computer, tablet, or smartphone
• • Documented VUS in an inherited cancer gene