Genetic Studies of Strabismus, Nystagmus, and Associated Disorders

Launched by BOSTON CHILDREN'S HOSPITAL · Feb 23, 2021

Keywords

ClinConnect Summary

This clinical trial is studying genetic factors related to strabismus (when the eyes are not aligned) and nystagmus (involuntary eye movement) to understand how these conditions may run in families. Researchers are looking for families that have multiple members affected by strabismus, as well as individuals with a specific type of strabismus called infantile esotropia or those with infantile nystagmus, along with their parents and siblings. By examining the DNA of these families, the study aims to identify genetic variations that may contribute to these eye conditions.

To participate in this study, you need to be part of a family with at least three relatives who have strabismus, or have a family member with infantile esotropia or infantile nystagmus. Both affected and non-affected family members are welcome to join. Participants can expect to provide DNA samples through blood or saliva, which will help researchers learn more about the genetic causes of these conditions. This research is important as it may lead to better understanding, diagnosis, and treatment options for strabismus and nystagmus in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • - Member of a family with at least 3 biological relatives with strabismus. (Both affected and non-affected family members will be enrolled).
• • OR
• • - Member of a family with at least 1 individual with infantile esotropia. (Both affected and non-affected family members will be enrolled).
• • OR
• • - Member of a family with at least 1 individual with infantile nystagmus. (Both affected and non-affected family members will be enrolled).
• Exclusion Criteria:
• • paralytic strabismus in affected family members