High Frequency Oscillatory Ventilation Versus High Frequency Jet Ventilation for Congenital Diaphragmatic Hernia

Launched by UNIVERSITY OF UTAH · Feb 24, 2021

Keywords

ClinConnect Summary

This clinical trial is studying two different types of breathing support for newborns with a condition called congenital diaphragmatic hernia (CDH), which affects how their lungs develop. The goal is to find out which method—high frequency jet ventilation (HFJV) or high frequency oscillatory ventilation (HFOV)—helps these babies breathe better after birth. In this trial, babies admitted to the University of Utah or Primary Children's Hospital within 24 hours of birth and who need help breathing will be randomly assigned to receive either HFJV or HFOV.

To be eligible for the trial, babies must be less than 24 hours old, require mechanical ventilation, and have an arterial line in place for monitoring. The study will compare how well the two ventilation methods work in terms of oxygen and overall blood flow. Parents can expect to give consent for their baby's participation, and this research is important in improving care for infants with CDH. The trial is currently recruiting participants, and all eligible babies can take part, regardless of gender.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Admitted to either the University of Utah and/or Primary Children's Hospital NICU within 24 hours of birth
• • 2. Requiring mechanical ventilation
• • 3. Umbilical arterial line or peripheral arterial line in place
• • 4. Obtained signed consent
• • 5. Infant is ≤ 24 hours of age
• Exclusion Criteria:
• • 1. Severe anomaly
• • 1. Chromosomal abnormalities
• • 2. Major congenital anomalies, including cardiac, central nervous system and syndromes
• • 2. Post-natal diagnosis \> 24 hours of life
• • 3. Unable to obtain consent for participation
• • 4. Unable to randomize within 24 hours of life