Total Post-thyroidectomy Hypocalcemia After Preoperative Cholecalciferol Supplementation

Launched by HÔPITAL NOVO · Feb 26, 2021

Keywords

ClinConnect Summary

This clinical trial is investigating whether taking vitamin D3 (also known as cholecalciferol) before having total thyroid surgery can help prevent low calcium levels (hypocalcemia) after the operation. Low calcium levels can be a common issue after this type of surgery, and the researchers want to see if vitamin D3 can make a difference in keeping calcium levels stable.

To be eligible for this study, you need to be at least 18 years old and scheduled for a total thyroidectomy, which is the complete removal of the thyroid gland. You should also have a health insurance plan that covers you. However, you won't be able to participate if you've had similar surgeries before, have certain health conditions like severe kidney or liver problems, or have taken vitamin D supplements in the last three months. If you decide to join, you will receive more information and will need to give your consent before starting. Overall, this trial aims to improve patient care by exploring new ways to manage calcium levels after surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient ≥ 18 years old
• • Patient shall be operated on for a total thyroidectomy in one time for any indication
• • Written informed consent (IC) obtained
• • Patients with affiliation to the social security system
• Exclusion Criteria:
• • • Medical history of : Thyroid or parathyroid surgery Hyperparathyroidism Granulomatosis flare-up
• • Hypocalcemia, hypercalcemia/ hypercalciuria, or symptom of Hypocalcemia, hypercalcemia/ hypercalciuria, not due to thyroid pathologies
• • Chronic kidney disease grade ≥4
• • Severe liver failure
• • 25OHD supplementation within last 3 months before surgery
• • Malabsorption syndrome
• • Known hypersensitivity to vitamin D
• • Medical history of calcic lithiasis
• • Pregnant women
• • Vulnerable populations (guardianship or trusteeship)
• • Allergies to one of the components of the fruit juice