Surfactant for Neonatal Respiratory Distress Syndrome(NRDS) and Neonatal Acute Respiratory Distress Syndrome(NARDS)

Launched by DAPING HOSPITAL AND THE RESEARCH INSTITUTE OF SURGERY OF THE THIRD MILITARY MEDICAL UNIVERSITY · Mar 1, 2021

Keywords

ClinConnect Summary

This clinical trial is studying the use of a treatment called pulmonary surfactant to help preterm infants who are experiencing respiratory distress syndrome (NRDS) or acute respiratory distress syndrome (NARDS). Pulmonary surfactant is a substance that helps keep the lungs open and functioning properly, and it has been a significant advancement in reducing complications and deaths in premature babies with breathing difficulties. However, the effectiveness of this treatment varies, and researchers want to understand better who benefits from it, particularly in infants diagnosed with NARDS.

To participate in the trial, infants must be under 37 weeks gestation and admitted to the neonatal intensive care unit (NICU) within 24 hours after birth. They should be diagnosed with either NRDS or NARDS and receive at least one dose of surfactant. Unfortunately, infants with major congenital or chromosomal abnormalities, or certain upper respiratory issues, won't be eligible. If enrolled, participants will receive the surfactant treatment as part of their care, and the trial aims to gather more information on its impact. This research is important to ensure that preterm infants receive the most effective treatments for their breathing challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Eligibility requirements for neonates were as follows:
• • The gestational age is less than 37 weeks and admitted to neonatal intensive care unit(NICU) in 24 h after birth
• • The neonates will be diagnosed with NRDS or NARDS
• • The neonates will be at least administrated one dose of surfactant
• Exclusion Criteria:
• • one of the following criteria will be needed
• • major congenital anomalies
• • chromosomal abnormalities
• • upper respiratory tract abnormalities