Development of a Predictive Model for the Risk of Metastatic Disease in PPGLs, a Retrospective Cohort Study

Launched by RIGSHOSPITALET, DENMARK · Mar 8, 2021

Keywords

ClinConnect Summary

This clinical trial is focused on understanding a rare group of tumors called pheochromocytomas and paragangliomas (PPGLs), which can develop in the adrenal glands and other parts of the nervous system. These tumors sometimes spread to other parts of the body, and the study aims to find out more about the genetic factors that contribute to this risk. By analyzing medical records and samples from Danish patients with PPGLs, the researchers hope to create a tool that can predict how these tumors might behave in individual patients. This could lead to better screening and prevention strategies for patients and their families.

To participate in this study, you would need to be a Danish patient who has been diagnosed with PPGLs or has genetic variations linked to these tumors since 1996. There are no specific exclusions from the initial data collection, but if a patient does not have available tumor or blood samples, they would not be included later on. This research is still in the planning stages and is not yet recruiting participants, but it has the potential to greatly improve how these rare tumors are managed in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All Danish patients diagnosed with PPGLs or genetic variants that predispose to PPGLs since 1996 will be included.
• Exclusion Criteria:
• • None from the initial data collection. If there are no tumour tissue or blood samples from a patient in the biobanks they will subsequently be excluded.