Underlying Mechanisms of Obesity-induced Obstructive Sleep Apnea

Launched by BRANDON NOKES · Mar 9, 2021

Keywords

ClinConnect Summary

Obstructive sleep apnea (OSA) is a highly prevalent disease with major neurocognitive and cardiovascular sequelae. Obesity is a major risk factor for OSA, but the underlying mechanisms remain unclear. Given the rising prevalence of obesity and the lack of adequate therapies for some afflicted patients, further mechanistic work is clearly required. Bariatric surgery is being done increasingly with compelling outcome data emerging; however, clinical response to weight loss is highly variable. In some patients, OSA is not present at baseline, despite morbid obesity, in other patients, OSA reso...

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Eligibility criteria

• Inclusion Criteria:
• • - Men and women
• • Ages \>= 18-65 years old
• • BMI 35 kg/m2--and above
• • Scheduled for sleeve gastrectomy (bariatric surgery)
• Exclusion Criteria:
• • Any cardiovascular, pulmonary or renal disease other than well-controlled hypertension or asthma.
• • Pregnancy
• • Currently smoking
• • Any respiratory disorder other than OSA or well controlled asthma
• • contraindication to MRI