Pathogenicity of B and CD4 T Cell Subsets in Multiple Sclerosis

Launched by UNIVERSITY HOSPITAL, BORDEAUX · Mar 11, 2021

Keywords

ClinConnect Summary

This clinical trial is looking at different types of immune cells called B cells and CD4 T cells to understand how they might contribute to multiple sclerosis (MS), a condition that affects the nervous system. The goal is to identify which of these cells could be causing problems in various forms of MS, especially in the more progressive types. This understanding could lead to new treatment options for people living with MS.

To participate in this study, you need to be at least 18 years old, and either have been diagnosed with MS or have experienced a clinically isolated syndrome, which is a single episode of neurological symptoms that may be the first sign of MS. Participants will undergo blood tests or a procedure to collect spinal fluid as part of their routine care. It's important to note that pregnant or breastfeeding women and certain individuals who cannot provide consent are not eligible to take part. If you choose to participate, you will help researchers learn more about MS, potentially benefiting future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • male or female subjects ;
• • Age ≥ 18 years;
• • subjects with MS defined by 2010 revised McDonald criteria or presenting a clinical isolated syndrome;
• • patients for which a blood draw and / or lumbar puncture to collect CSF is performed for diagnostic or therapeutic purpose;
• • affiliated to an health insurance system;
• • and who agree to participate in the study.
• Exclusion Criteria:
• • Pregnant or breastfeeding women,
• • patient concerned by articles L 1121-5 to L 1121-8 (persons deprived of their liberty by a judicial or administrative decision, minors, persons of legal age who are the object of a legal protection measure or unable to express their consent)