Surgical Resection of Latent Brain Tumors Prior to Recurrence

Launched by MAYO CLINIC · Mar 19, 2021

Keywords

ClinConnect Summary

This clinical trial is exploring the effects and potential benefits of performing surgery on brain tumors before they return after treatment. For patients who have already received chemotherapy or radiation but still have some visible tumor left, this research aims to find out if having surgery early can lead to better outcomes compared to waiting for the tumor to come back or not having surgery at all.

To be eligible for this trial, participants need to be at least 18 years old, have a confirmed diagnosis of a brain tumor, and have previously undergone chemotherapy or radiation. They should also be willing to have surgery and be part of the Mayo Clinic Cancer Center program for studying nervous system tumors. If you join the study, you will receive close monitoring and care as researchers evaluate how early surgery impacts your health. This trial is currently recruiting participants of all genders, so if you or a loved one might be interested, it's a good idea to discuss it with your healthcare provider.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age \>= 18 years
• • Histological or cytological confirmation of brain tumor and/or suspected brain tumor based on clinical and radiologic findings
• • Prior chemotherapy and/or radiation treatment directed to the known/suspected tumor
• • Radiographic evidence of residual or previously unresected tumor
• • Willingness to undergo surgery and sign informed consent
• • Patients not currently eligible for an alternate competing interventional clinical trial
• • Enrollment in the Mayo Clinic Cancer Center Neuro-Oncology Program Registry for the study of Nervous System Tumors (IRB#12-003458)
• Exclusion Criteria:
• • Age \< 18 years
• • Found to be a member of a vulnerable population (e.g. pregnant, lacking capacity to consent) during the course of pre-enrollment or pre-surgical assessment
• • Prior gross total resection of brain tumor leading to absence of visible latent disease (exemption available for post-operative enrollment)
• • Any contraindication to surgery, including anyone who in the opinion of the surgeon is at unreasonably elevated risk of wound complications
• • Patients who have not yet undergone surgery or radiation, but who would be appropriate candidates for an alternate interventional clinical trial (e.g. post-operative fractionated vs single fraction radiation to the surgical cavity for surgical brain metastases)