Exercise Effects on Adipose Tissue Structure and Function

Launched by UNIVERSITY OF MICHIGAN · Mar 19, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how exercise affects fat tissue and overall health in people who are overweight or have metabolic issues, like insulin resistance. Participants will be divided into two groups: one group will follow an exercise program while the other will not exercise at all. Everyone will first go through a weight loss program where they will aim to lose 10% of their body weight. After this, they will switch to a high-calorie diet to regain some of the weight they lost, and then they will undergo several health tests again.

To be eligible for this study, participants should be between 18 and 40 years old, have a body mass index (BMI) between 27 and 45 (which means they are overweight), and not have exercised regularly for the past six months. Women must have regular menstrual cycles and cannot be pregnant or breastfeeding. Participants can expect to be involved in various tests related to their metabolism before and after the weight loss and regain phases. It's important to note that individuals with certain health conditions or those taking specific medications will not be able to participate. This study is currently recruiting participants, and it's a great opportunity to learn more about how exercise can influence health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age: 18-40
• • Body Mass Index: 27-45 kg/m2
• • No regularly planned exercise/physical activity for at least 6 months
• • Women must have regularly occurring menses and must be premenopausal
• Exclusion Criteria:
• • Evidence/history of cardiovascular or metabolic disease
• • Medications known to affect lipid or glucose metabolism, or inflammation
• • Weight instability ≥ ± 6 pounds in the last 3 months
• • Tobacco or e-cigarette users
• • Women must not be pregnant or actively lactating