Role NLRP3 Inflammasome in Weight Loss Following Sleeve Gastrectomy in Morbidly Obese Patients

Launched by UNIVERSITY HOSPITAL CENTER OF MARTINIQUE · Mar 22, 2021

Keywords

ClinConnect Summary

This clinical trial is investigating how inflammation in the body affects weight loss after a specific type of weight loss surgery called sleeve gastrectomy, particularly in women who are severely obese. The researchers believe that the amount of inflammation in fat tissue before surgery may influence how much weight a person loses and how well they maintain that weight loss afterward. This study is important because while sleeve gastrectomy can help many people lose weight and improve health, some patients do not experience the expected benefits.

To participate in this trial, women between the ages of 18 and 45 who have a body mass index (BMI) of 40 or more (or 35 with certain health issues) may be eligible. Participants will receive thorough information about the surgery and its risks, and they will be followed closely for two years after the operation. This study aims to understand better how inflammation affects weight loss, which could lead to improved treatments for obesity and related health problems in the future.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Being a woman between the ages of 18 and 45;
• • Have been well informed about bariatric surgery and perioperative risks and have benefited from a multidisciplinary evaluation by a multidisciplinary team (RCP) ;
• • Have a BMI greater than or equal to 40 kg/m2 or greater than or equal to 35 kg/m2 with at least one co-morbidity that can be improved after surgery (cardiovascular disease, sleep apnea and severe respiratory disorders, type 2 diabetes, osteoarticular diseases)
• • Have been informed of the research on the samples taken during care;
• • Having stated its decision not to object to the research on the samples taken during the treatment;
• • To have accepted medical and surgical follow-up for 24 months;
• • Patient under the general social security system.
• Exclusion Criteria:
• • Being a pregnant or nursing woman;
• • Being a type 1 diabetic;
• • Have inflammatory bowel disease;
• • Have severe and unstable eating disorders ;
• • Have severe, uncontrolled cognitive, mental or psychological disorders;
• • Have a cancerous pathology;
• • Be addicted to alcohol and psychoactive substances (both legal and illegal);
• • Have a life-threatening illness in the short or medium term;
• • Have contraindications related to surgical operations in general such as general anaesthesia;
• • Be under legal protection measures (guardianship, curators, safeguarding of justice), and person deprived of liberty.