Spinal Cord Lesion Detection in Multiple Sclerosis Using Novel MRI Sequences

Launched by UNIVERSITY HOSPITAL, BASEL, SWITZERLAND · Mar 24, 2021

Keywords

ClinConnect Summary

This clinical trial is investigating a new MRI technique called averaged magnetization inversion recovery acquisitions (AMIRA) to see how well it can detect lesions (damaged areas) in the spinal cords of people with Multiple Sclerosis (MS). The main goal is to find out how accurately this new method works compared to standard approaches and to understand its potential benefits in clinical practice. The study is currently looking for participants aged 65 to 74 who have been diagnosed with MS and are not currently on steroids.

To be eligible for the trial, participants must meet certain criteria, including being part of the Swiss MS Cohort study and not having any severe neurological or psychiatric conditions that affect the spinal cord. Those with specific medical devices (like pacemakers) or conditions that might make an MRI difficult (such as claustrophobia) cannot participate. If you join the study, you can expect to undergo MRI scans using the new technique, and your results will help researchers learn more about how to improve the detection of MS-related spinal cord lesions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of multiple sclerosis according to established international criteria
• • Steroid free period: \> 4 weeks
• • Participation in the Swiss MS Cohort (SMSC) study
• Exclusion Criteria:
• • . History of severe (other) neurological, internal or psychiatric disease with SC affection
• * MRI-related exclusion criteria (questionnaire):
• • 1. Paramagnetic and/or superparamagnetic foreign objects in the body (especially when located close to the SC)
• • 2. Pacemaker
• • 3. Claustrophobia
• • 4. Pregnancy, lactation
• • 5. Known hypersensitivity to gadolinium-based contrast media