Exercise Capacity According to Coronary Microvascular Dysfunction and Body Composition

Launched by KOREA UNIVERSITY ANAM HOSPITAL · Mar 29, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how the function of tiny blood vessels in the heart and body composition (like muscle and fat levels) affect exercise capacity in patients with heart failure with preserved ejection fraction (HFpEF), a condition where the heart pumps normally but still causes symptoms like shortness of breath or chest pain. The researchers want to understand how well patients can exercise and if their heart and body conditions play a role in that.

To participate in this trial, you must be between 20 and 80 years old and experience chest pain or breathlessness, but not have serious blockages in your heart arteries. You should also be able to exercise on a treadmill or stationary bike. If you have certain heart conditions, severe kidney issues, or other specific health problems, you may not be eligible. Participants will undergo tests to evaluate their heart and body functions and may learn more about how these factors influence their ability to exercise. This study is currently looking for volunteers, and it aims to help improve understanding and treatment for people living with HFpEF.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 20 to 80
• • Typical/atypical chest pain or ischemic symptoms including dyspnea
• • No significant coronary artery stenosis (\>50% stenosis) in coronary angiography or computed tomography
• • Left ventricular ejection fraction ≥50%
• Exclusion Criteria:
• • More than moderate valvular heart disease
• • Congenital heart disease
• • Chronic renal failure (estimated glomerular filtration rate \<30 ml/min/1.73m2) or end-stage renal failure undergoing hemodialysis or peritoneal dialysis
• • Asthma, chronic obstructive pulmonary disease and primary pulmonary hypertension
• • Receiving anticancer drugs
• • Vasculitis associated with autoimmune diseases
• • Patients with difficulty in performing exercise load evaluation (treadmill, bicycle ergometer)
• • Atrial fibrillation
• • Atrioventricular block with more than second degrees, symptomatic bradycardia, cryo-node failure syndrome, Wolff-Parkinson-White (WPW) patients