Neurocognitive Disorders After Major Surgery in Elderly

Launched by CIUSSS DE L'EST DE L'ÎLE DE MONTRÉAL · Mar 29, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how a specific type of anesthesia, guided by brain activity monitoring, affects the mental function of older adults after major surgery. The researchers want to see if adjusting anesthesia based on brain signals can reduce the risk of neurocognitive disorders (NCDs) in patients aged 70 and older who are having major non-heart surgeries. Participants will be randomly assigned to either the EEG-guided anesthesia group, where their anesthesia levels are carefully controlled based on brain activity, or to a control group, where standard anesthesia methods are used.

To qualify for the study, patients must be at least 70 years old and scheduled for a significant surgery that will take more than an hour under general anesthesia. They should not have any severe cognitive impairments, such as dementia, and must be able to communicate in either French or English. Participants can expect to undergo cognitive testing before and after surgery to assess any changes in their mental function. This study is currently recruiting, and it aims to provide valuable insights into improving recovery for older patients after surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients 70 years of age or older,
• • Major gynecologic, abdominal, urologic, thoracic or orthopedic surgery via laparoscopy or laparotomy under general anesthesia - with or without concomitant use of regional or neuraxial anesthesia -,
• • Expected anesthesia time of more than 60 minutes,
• • Seen for assessment by internal medicine and/or anesthesiology at the preoperative clinic (CIEPC)
• Exclusion Criteria:
• • Known diagnosis of dementia or other neurological, psychiatric, developmental or medical condition that resulted in documented severe cognitive impairment,
• • Emergency surgery,
• • Significant auditory or visual impairment that precludes participation in cognitive testing,
• • Known allergy or intolerance or other medical condition that precludes the use of prescribed general anesthesia protocol for this study,
• • Inability to communicate in French or English.