The "MyoThrombus" Study

Launched by UNIVERSITY OF EDINBURGH · Mar 31, 2021

Keywords

ClinConnect Summary

The "MyoThrombus" study is looking into a condition called left ventricular thrombus, which can happen after a heart attack. This condition can lead to serious problems like strokes and further heart issues. The goal of the study is to better understand how these blood clots form and how they can be treated. Researchers will use advanced imaging techniques to examine patients who have recently had a heart attack and check for any signs of these clots or subclinical strokes, which are strokes that may not have obvious symptoms.

To participate in this study, you need to be over 40 years old and have experienced a specific type of heart attack within the last few weeks. If you join, you will undergo imaging tests about a week after your heart attack, and if blood clots are found, you may be given blood-thinning medication for a few months. You'll also have follow-up imaging to see how things progress. This study is important because it aims to improve our understanding of these blood clots and find better ways to treat them, but it's not for everyone, especially if you have certain health conditions or are pregnant.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or females over the age of 40 with recent (within 21±2 days) acute type 1 anterior myocardial infarction
• • Provision of informed consent prior to any study specific procedures
• Exclusion Criteria:
• • Inability or unwilling to give informed consent.
• • Concomitant use of anticoagulation agents (warfarin, apixaban, edoxaban, rivaroxaban, dabigatran or SC/IV Heparin) (Cohort 1 only)
• • Unable to tolerate the supine position
• • Impaired renal function with eGFR of \<30 mL/min/1.73m2
• • Severe or significant comorbidity
• • Women who are pregnant or breastfeeding • Severe claustrophobia