Periodontitis and Inflammation

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Apr 2, 2021

Keywords

ClinConnect Summary

This clinical trial is focused on understanding periodontitis, a serious gum disease that can lead to tooth loss and other health issues. Researchers aim to identify specific biological markers that reflect how the disease is affecting the body. By studying samples from people with advanced periodontitis and those with healthy gums, the trial hopes to uncover important information about the disease's causes and how it impacts overall health. The findings could help improve prevention and treatment strategies for periodontitis.

To be eligible for this study, participants must be at least 18 years old, speak and understand French, and agree to take part. They will either be individuals diagnosed with stage 3 or 4 periodontitis or those with healthy gums needing certain dental procedures. Participants can expect to provide biological samples, such as saliva and gum tissue, which will be collected before and during their treatment. It's important to note that individuals who have recently taken antibiotics or are pregnant cannot participate. This trial could lead to better understanding and treatment of gum disease, benefiting many people in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Common criteria for all patient groups
• • Patient \> 18 years old
• • Patient affiliated to a social security system, beneficiary or beneficiary of a right other than AME
• • Patient who speaks and understands French well enough to be able to read and understand the study information note.
• • Patient who does not object to his participation in the study
• Specific criteria:
• • - Case Periodontitis: Patient with localized or generalized periodontitis, stage 3 or 4. The diagnosis of periodontitis is based on the elements found during the interview and clinical examination
• • - Case peri-implantitis: Patients with at least 1 implant affected by peri-implantitis. Diagnosis is based on the findings of the interview, clinical examination and radiographic examination.
• Control group:
• • Patient with gingival health on intact or reduced periodontium with no history of periodontitis or peri-implantitis and requiring surgical care such as dental avulsion and pre-prosthetic periodontal corrective/aesthetic surgeries (coronal elongation, neck alignment.)
• Exclusion Criteria:
• • Patients who have received antibiotic prophylaxis, antibiotic therapy, or anti-inflammatory treatment within 3 months prior to inclusion
• • Pregnant or breastfeeding women
• • Patient included in another interventional research protocol or in a period of exclusion.
• • Patients under guardianship, curatorship or legal protection.
• • Patient having expressed his opposition to participate in the research