The Effects of Acute Melatonin Supplementation on Cardiovascular Responses to Sympathetic Activation
Launched by UNIVERSITY OF OKLAHOMA · Apr 1, 2021
Trial Information
Current as of May 01, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying how a supplement called melatonin affects the heart and blood vessels during stress, specifically when exposed to cold and during exercise. Researchers want to see if taking melatonin can change how the body responds to these situations. The trial is currently looking for healthy men and women between the ages of 65 and 74. Women who want to participate must be premenopausal and have regular menstrual cycles.
If you qualify and decide to join the study, you will be asked to perform some tests while resting and during exercise to see how your cardiovascular system reacts after taking melatonin. To be eligible, you should not have any history of heart or blood pressure issues, diabetes, or be a regular user of melatonin or certain medications. This trial is a chance to contribute to research that could help us understand more about the effects of melatonin on heart health.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Healthy men and women
- • Women must be premenopausal with a regular menstrual cycle (26-30 days)
- Exclusion Criteria:
- • History of autonomic dysfunction
- • Cardiovascular diseases
- • Diabetes
- • Tobacco/nicotine use
- • Systolic Pressure \>= 130 mmHg
- • Diastolic Pressure \>= 85 mmHg
- • Regular melatonin use \>= 1 use/week
- • Allergy to melatonin
- • Cardiometabolic medication use (e.g. anti-hypertensives, insulin-sensitizing, statins)
- • Sex hormone replacement medical use (e.g. testosterone, estrogen, progesterone)
- • Pregnancy
About University Of Oklahoma
The University of Oklahoma, a leading research institution, is dedicated to advancing healthcare through innovative clinical trials and research initiatives. With a robust network of interdisciplinary experts and state-of-the-art facilities, the university fosters an environment that promotes scientific discovery and the development of new treatments. Its commitment to patient-centered research ensures that clinical trials not only adhere to the highest ethical standards but also aim to address pressing health challenges. By collaborating with various stakeholders, including industry partners and healthcare providers, the University of Oklahoma seeks to translate research findings into tangible benefits for communities, ultimately enhancing the quality of care and improving health outcomes.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Norman, Oklahoma, United States
Patients applied
Trial Officials
Jeremy M Kellawan
Principal Investigator
University of Oklahoma
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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