Reversing Glucose and Lipid-mediated Vascular Dysfunction

Launched by UNIVERSITY OF KANSAS MEDICAL CENTER · Apr 2, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how glucose and fat in our diet affect blood vessels in healthy adults and if these changes can lead to high blood pressure. Researchers want to understand the connection between these factors to help prevent hypertension in the future. The trial is currently looking for participants who are lean, with a Body Mass Index (BMI) under 25, and who have normal blood pressure and insulin sensitivity. Eligible participants should be between 18 and 79 years old and have stable weight over the last three months.

If you decide to join the study, you may need to stop taking certain supplements for two weeks before participating. As a participant, you can expect to undergo assessments to measure how your blood vessels respond to glucose and fat. It's important to note that individuals with diabetes, high blood pressure, a history of heart or vascular disease, or current smokers cannot participate. This study aims to provide valuable insights into how diet affects blood vessel health, which could lead to better ways of managing blood pressure in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Lean: BMI \< 25 kg/m
• • Normal insulin sensitivity: (calculation based on fasting glucose and insulin concentrations in blood)
• • Middle-aged: 18-79 years
• • Blood pressure: \< 140 (systolic) and \< 90 mmHg (diastolic
• • Weight stable (+/- 5 lbs) for the previous 3 months
• • Participants must be willing and able to discontinue taking any vitamin C or E supplements or omega-3 fatty acids beginning 2 weeks prior.
• • Able and willing to provide written informed consent
• Exclusion Criteria:
• • Diabetes mellitus Type I or Type II: fasting glucose \< 126 mg/dL and/or HbA1c \< 6.5%
• • Current smoker or History of smoking in the past 3 months.
• • Hyperlipidemia: Fasting triglycerides \< 250 mg/dL
• • Hypertension: \>130/80 mmHg
• • History of heart disease (e.g., myocardial infarction, stent, heart attack, stroke, heart failure, valvular heart disease, cardiomyopathy)
• • History of vascular disease (e.g., bypass, stroke)