Image Assisted Optimization of Proton Radiation Therapy in Chordomas and Chondrosarcomas

Launched by LEIDEN UNIVERSITY MEDICAL CENTER · Apr 1, 2021

Keywords

ClinConnect Summary

This clinical trial is studying the use of advanced imaging techniques to better understand and treat two types of bone tumors called chordomas and chondrosarcomas, which often occur in the spine and can be quite aggressive. The researchers want to see if special MRI scans can show changes in these tumors sooner than traditional methods, allowing doctors to adjust treatment more effectively. The study will involve patients who have been diagnosed with these tumors and are scheduled to receive proton beam therapy, a type of targeted radiation treatment.

Eligible participants include adults over the age of 50 who have been diagnosed with either primary or recurrent chordoma or chondrosarcoma and have agreed to receive proton beam therapy. If you join the trial, you will undergo a few extra MRI and PET-CT scans during your treatment, but these will not affect your overall care. The goal is to gather valuable information that might help improve treatment outcomes for future patients with similar conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Histologically diagnosed with primary or recurrent chordoma or chondrosarcoma in the axial skeleton (clivus, spine and sacrum)
• • Accepted for standard proton beam therapy
• Exclusion Criteria:
• • Diagnosis other than chordoma or chondrosarcoma is made.
• • Patient refuses (parts) of the standard treatment protocol.
• • Patient refuses MRI due to claustrophobia.
• • Patient not suitable for MRI due to the presence of MRI incompatible implants.
• • Incapacitated patients.
• • Patient doesn't allow coded data to be used for analysis.
• • Patient is under 50 years of age.
• • Lesion size less than 1cm.
• • Patients with WHO 3 and higher.