Transorbital Ultrasound and Other Markers for Prognosis Prediction After Cardiac Arrest

Launched by UNIVERSITY HOSPITAL PILSEN · Apr 6, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how well a specific ultrasound technique, called measuring the optic nerve sheath diameter (ONSD), can help predict outcomes for patients who have experienced a cardiac arrest and have regained circulation. After a cardiac arrest, one of the biggest concerns is potential brain damage, which can affect a patient's chances of recovery. The goal of this study is to see if measuring ONSD can help doctors understand how severe the brain injury might be compared to other established methods.

To be eligible for this trial, participants must be at least 18 years old and have suffered a non-traumatic cardiac arrest, meaning their heart stopped suddenly due to medical reasons, not an injury. They should also have a Glasgow Coma Scale score of 7 or lower (which indicates a more severe level of consciousness) shortly after regaining circulation. If someone joins the study, they can expect to have their optic nerve sheath measured using a quick and painless ultrasound within the first day after their cardiac arrest. This study is important as it could help improve how doctors predict recovery after such serious events, potentially guiding better treatment decisions for patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age of 18 years or older
• • out of hospital cardiac arrest of non-traumatic cause with CPR and subsequent ROSC
• • Glasgow coma scale (GCS) ≤ 7 or sedation 30 minutes after ROSC achievment
• Exclusion Criteria:
• • unavailable first measurment of the optic nerve sheath diameter (ONSD) measured by transorbital ultrasonography 24±6 hours after ROSC achievement
• • refractory cardiac arrest
• • craniocerebral injury
• • intracranial tumor
• • active intracranial bleeding
• • haemorrhagic stroke and/or subarachnoid haemorrhage in the last 3 months
• • facial trauma affecting the eye area
• • active neuroendocrine tumor, small cell lung cancer, non-small cell lung
• • CPC 3-5 before cardiac arrest
• • sclerosis multiplex and/or optic neuritis of other etiology