Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)

Launched by UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER · Apr 8, 2021

Keywords

ClinConnect Summary

The OB-HTN clinical trial is studying how our nervous system affects blood pressure, especially during times of stress, and how conditions like obesity and hypertension (high blood pressure) play a role in this process. Researchers will measure how active the nervous system is and how blood flows in the body during activities that can cause stress, like exercise or low oxygen levels. This will help them understand the connection between these conditions and nervous system function.

To participate, you should be between 18 to 55 years old and fall into one of a few categories: you could be a healthy individual with a body mass index (BMI) under 30, or someone who is obese (BMI over 30) or has high blood pressure. It's important to note that certain health issues, like serious heart or kidney disease, diabetes, or a history of smoking, may prevent you from joining the study. If eligible, participants can expect to engage in some stress tests and receive infusions of medications that either widen or narrow blood vessels, helping researchers gather valuable information about how these conditions affect blood pressure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Control - BMI\<30, age 18-55
• • Hypertensive - BMI\<30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Obese- BMI\>30, age 18-55 Obese-hypertensive- BMI\>30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring
• Exclusion Criteria:
• • All groups - presence of other significant cardiovascular disease, renal disease, history of smoking, diabetes,