Biometabolic Outcomes After Weight Loss Surgery: An Individualized Approach

Launched by UNIVERSITY OF MISSOURI-COLUMBIA · Apr 8, 2021

Keywords

ClinConnect Summary

Outcomes after weight loss surgery are quite variable with some patients regaining a significant amount of weight in the postoperative period. Increasing evidence suggests gastric bypass leads to weight loss and improvement in associated metabolic illness through mechanisms other than just restriction and malabsorption and may include circulating bile acids, gut hormones, genetic/epigenetic variability, changes in gut microbiota as well as other mechanisms. Whether modifications to bypassed intestine length may improve outcomes after gastric bypass has not been adequately studied with incon...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age greater than 18
• • 2. Body mass index of 40-60 kg/m2
• • 3. Meet insurance criteria, as set forth by the patient's insurance policy, to qualify for coverage for weight loss surgery
• • 4. Planned laparoscopic Roux-en-Y gastric bypass
• • 5. Willingness to have blood collected before and after surgical procedure at defined points and collect and mail stool sample before operation and at defined post-operative time points.
• Exclusion Criteria:
• • 1. Age less than 18
• • 2. Patient fails to fulfill insurance mandated criteria
• • 3. Unwilling to be randomized to variable length to gastric bypass or unwilling to have blood collected or personally collect and mail in stool sample
• • 4. Unwilling to follow-up at required postoperative visits