MISC COVID-19 Study in Pediatric Population

Launched by TUBERCULOSIS RESEARCH CENTRE, INDIA · Apr 13, 2021

Keywords

ClinConnect Summary

The MISC COVID-19 Study is looking at how COVID-19 affects children, particularly those who may develop a serious condition known as multisystem inflammatory syndrome in children (MIS-C). This study aims to understand the immune responses in children infected with the virus and how different strains of the virus might influence the severity of their illness. It’s important because while COVID-19 is generally less severe in children than in adults, some children can still become very sick.

To be eligible for this study, children between the ages of 1 and 15 can participate if they meet certain criteria. For example, they may have had a positive or negative test for COVID-19, but it’s necessary for parents to provide consent. Participants will be asked about their health and might undergo tests to check their immune response. This research is currently recruiting children who are being treated in clinics or hospitals in Chennai, and it aims to gather valuable information that could help in understanding how to better care for children affected by COVID-19 and MIS-C.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Children between 1 to 15 years of age
• • Willing to provide informed consent (parents)/assent
• • For Group 1 - Positive or Negative for COVID-19 by RT-PCR but positive for SARS-CoV2 IgG
• • For Group 2 - Positive for COVID-19 by RT-PCR but negative for SARS-CoV2 IgG
• • For Group 3 - Positive for COVID-19 by RT-PCR or positive for SARS-CoV2 IgG antibody
• • For Group 4 - Control children who are negative for both RT-PCR and IgG antibody
• Exclusion Criteria:
• • Severely immunocompromised or anemic (WHO criteria in children) or malnourished
• • History of any illness or condition which, in the investigator's judgment, may substantially increase the risk associated with the participant's participation in the protocol, or compromise the scientific objectives