Cardiac Tissue Sodium Assessment in CKD Patients Using Sodium MRI

Launched by LONDON HEALTH SCIENCES CENTRE RESEARCH INSTITUTE OR LAWSON RESEARCH INSTITUTE OF ST. JOSEPH'S · Apr 15, 2021

Keywords

ClinConnect Summary

This clinical trial is exploring how much sodium (salt) builds up in the heart muscle of patients with chronic kidney disease (CKD) and whether this build-up is linked to heart problems. Sodium can accumulate in the body when the kidneys are not working well, and this study aims to use a special type of MRI called sodium MRI to measure the salt levels in the heart. Researchers will compare the results from CKD patients, those on dialysis, and healthy volunteers to see if high sodium levels are related to any heart issues.

To participate in this study, you need to be at least 18 years old. If you have CKD, you should have had the disease for over three months without needing dialysis yet. If you are on dialysis, you should have been receiving treatment for more than three months. Healthy volunteers are also welcome, but they should not have kidney disease, heart disease, diabetes, liver issues, or swelling in the legs. Participants will undergo MRI scans to check sodium levels and heart function, which can help researchers understand how to better treat heart problems related to kidney disease in the future. It's important to know that individuals with certain medical devices or conditions, like pregnancy or claustrophobia, may not be eligible for the study.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Age greater than or equal to 18 years
• • For patients on maintenance hemodialysis: more than 3 months duration of therapy
• • For patients with CKD: evidence of kidney disease persisting \> 3 months and no indications to start dialysis
• • For healthy controls: lack of kidney disease, cardiovascular disease, diabetes, liver cirrhosis and peripheral edema
• Exclusion Criteria:
• • Pregnant, breastfeeding or intending pregnancy
• • Contraindication to MRI scan
• • Inability to tolerate MRI due to patient size and/or known history of claustrophobia.
• • Mechanically implanted, electrically, or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, tattoos, shunt, surgical staples (including clips or metallic sutures and/or ear implants.)