Treatment Strategy to Enhance Nrf2 Signaling in Older Adults

Launched by NORTHERN ARIZONA UNIVERSITY · Apr 16, 2021

Keywords

ClinConnect Summary

This clinical trial is looking at how exercise can be improved for older adults by adding phytonutrients, which are natural compounds found in vegetables like broccoli and kale. As we age, our bodies may not respond as well to exercise, so this study aims to find out if these plant-based nutrients can help enhance the benefits of physical activity for older individuals.

To participate, you need to be a man or woman aged 60 or older and able to give your own consent. You should also have a certain level of fitness, which will be determined through a screening process. However, some people may not qualify, including those who take certain medications, have specific health conditions, or have a high body weight. If you join the study, you'll likely engage in exercise sessions and receive the phytonutrient treatment, all while helping researchers understand how to improve health and fitness in older adults.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Men and women, 60 years and older
• • Competent to independently give informed consent
• • Successful completion of screening
• * Maximal oxygen consumption below the 60th percentile based on gender:
• • Women: ≤ 21.2 mL/kg/min
• • Men: ≤ 30.5 mL/kg/min
• Exclusion Criteria:
• • Estrogen supplementation (in any form) within the previous 6 months
• • Any medication that could affect outcome measures such as statins, blood pressure medications, or anti-depressives
• • Use of anti-oxidant supplements, in excess of standard multi-vitamins (1 tablet/day) and/or any supplements known to target Nrf2 including resveratrol, Protandim, and sulforaphane
• • Current smoker
• • Body Mass Index (BMI) greater than 33 kg/m2 (Class I Obesity)
• • Any chronic illness that could affect outcome measures, including diabetes, liver or renal disease, or cancer (other than skin cancer)
• • History of a myocardial infarction within the last 6 months, clinically significant aortic stenosis, use of cardiac defibrillator, or uncontrolled angina
• • Clinically significant arrhythmia on a resting EKG or significant EKG changes during the baseline VO2 max test
• • Any other condition that would contraindicate maximal exercise testing, including elevated blood pressure at rest (systolic BP \>150 or diastolic BP \>90 mm Hg on at least 2 measurements, at least 10 minutes apart) or musculoskeletal problems