Tissue Collection for Drug Screening and Bioanalysis

Launched by WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY · Apr 16, 2021

Keywords

ClinConnect Summary

This clinical trial is focused on studying central nervous system (CNS) tumors to better understand their characteristics and improve treatment options. Researchers will collect tissue samples during surgeries and from patients who have passed away. These samples will help create models that can be used to test how different drugs affect the tumors. Ultimately, the goal is to discover new ways to treat these tumors more effectively.

To participate in this study, individuals undergoing neurosurgery for a suspected CNS tumor, along with their parents, may be eligible. This includes patients of all ages, even newborns and pregnant individuals. There is also a group for patients without CNS tumors between the ages of 4 weeks and 21 years. Participants can expect to donate extra tissue that is not needed for their medical diagnosis, and their contributions will play an important role in advancing research to improve therapies for CNS tumors.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria for Tumor patients undergoing neurosurgery (cohort 1)
• • 1. Subject has presented with a suspected/confirmed neoplastic CNS lesion and is undergoing a neurosurgical procedure in which CNS tissue and/or tumors associated with this tissue will be removed.
• • 2. There must be tissue available in excess of that required by neuropathology for diagnostic purposes.
• • 3. Subject of all ages included.
• • 4. Subjects who are pregnant can be included.
• • 5. Subjects who are neonates (0-4 weeks) can be included.
• • Inclusion Criteria for Non-tumor patients undergoing neurosurgery (cohort 2)
• • 1. Subject is between 4 weeks and 21 years of age and is undergoing a neurosurgical procedure at WCMC.
• • 2. Subject does not have a CNS tumor diagnosis.
• • 3. Subject should not be pregnant at the time of enrollment.
• • Inclusion Criteria for Autopsy tumor tissue donation (cohort 3)
• • 1. Subject of all ages included
• • 2. Subject has been diagnosed with a neoplastic CNS lesion at the time of passing.
• • 3. Subjects who are pregnant can be included.
• • 4. Subjects who are neonates (0-4 weeks) can be included.
• • Inclusion Criteria for parent of tumor patients
• • 1. Subject is the biological parent of a patient undergoing/ who underwent a neurosurgical procedure in which CNS tissue and/or tumors associated with this tissue will be/ was removed.
• • 2. Subject is the biological parent of patient enrolled in cohort 1.
• • 3. Subject is not pregnant at the time of enrollment.