SBRT vs. Conventional Fractionation With HDR Boost for Prostate Cancer

Launched by DR. GERARD MORTON · Apr 26, 2021

Keywords

ClinConnect Summary

This clinical trial is looking at two different ways to treat prostate cancer: a method called SBRT (Stereotactic Body Radiation Therapy) and a more traditional approach that uses a combination of standard radiation and a boost from HDR (High-Dose Rate) brachytherapy. The goal is to see which treatment works better for men with prostate cancer. The trial is currently recruiting participants who are men aged 18 and older, with a confirmed diagnosis of prostate adenocarcinoma, and who haven't received certain previous treatments for prostate cancer.

If you or a family member are considering joining this trial, you will be asked to sign a consent form agreeing to participate. Participants will be randomly assigned to receive either SBRT or the conventional treatment option. To be eligible, participants should not have advanced cancer that has spread to other parts of the body and should be generally healthy enough to undergo the treatments. Throughout the trial, participants will be asked to complete some questionnaires about their health and experience. This study aims to help doctors find the best treatment options for prostate cancer in the future.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Age 18 or older
• • Informed consent for treatment and study participation completed
• • Pathologically proven diagnosis of prostate adenocarcinoma
• • ECOG Performance Status 0-2
• • No prior history of pelvic radiotherapy, brachytherapy, cryosurgery, HIFU, TURP or radical prostatectomy
• Exclusion Criteria:
• • Presence of nodal or distant metastasis on staging MRI or CT Abdomen/Pelvis and Bone scan within 90 days of enrolment (CT/MRI/Bone Scan are only required if the clinical risk of metastatic disease is sufficient to warrant these scans)
• • Plan for adjuvant chemotherapy post-radiotherapy
• • Serious medical comorbidities or other contraindications to HDR brachytherapy
• • Presence of inflammatory bowel disease
• • Presence of connective tissue disorder seen as a contraindication to radiotherapy
• • Medically unfit for general/spinal anesthesia
• • Unable or unwilling to complete questionnaires