Sarcopenia Magnetic Resonance Imaging Evaluation (SUSIE)
Launched by THE CLEVELAND CLINIC · Apr 28, 2021
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
The SUSIE trial is looking to study a new imaging technique called Magnetic Resonance (MR) Fingerprinting and another method called Phosphorus-31 MR Spectroscopy (P-MRS). These methods will help researchers understand the muscles of people with heart failure, especially those who also have a condition called sarcopenia, which is the loss of muscle mass and strength. By comparing heart failure patients with and without sarcopenia, the trial aims to create detailed profiles of their muscle characteristics.
To be eligible for the trial, participants need to be at least 40 years old and have stable chronic heart failure with specific heart function issues. Healthy volunteers without heart failure or sarcopenia can also take part. However, there are some health conditions and medical devices that may disqualify individuals from participating, especially if they have advanced diseases or certain implants that are not safe for MRI scans. Participants will undergo MRI scans to gather important information about their muscle health, which may help improve treatments for heart failure in the future.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Heart failure patients
- • Age ≥40 yrs
- • Stable chronic heart failure
- • Systolic dysfunction determined by cardiac MRI with left ventricle ejection fraction 40% or less
- • Healthy Volunteers
- • Age ≥40 yrs
- • No diagnosed heart failure or sarcopenia
- Exclusion Criteria:
- • Heart failure patients
- • • Advanced liver disease, advanced cancer, advanced chronic obstructive pulmonary disease
- • Healthy volunteers (controls)
- • Advanced liver disease, advanced cancer, advanced chronic obstructive pulmonary disease
- • Contraindications to MRI Contraindications to MRI
- • Heart pacemaker/defibrillator
- • Electronic/implanted stimulators or devices, including deep brain stimulator, vagus nerve stimulator, bladder stimulator, spine stimulator, neurostimulators; implanted electrodes or wires
- • Cochlear implant or other ear implants
- • Implanted drug pumps (insulin, narcotic/pain medications, drugs to treat spasticity)
- • Programmable shunt
- • Aneurysm clips and coils
- • Stents
- • Filters (for example, blood clot filters)
- • Metal fragment in body or eye (eg, BBs, bullets, shrapnel, metal pieces or shavings)
About The Cleveland Clinic
The Cleveland Clinic is a renowned nonprofit academic medical center based in Cleveland, Ohio, recognized for its commitment to advancing healthcare through innovative research and clinical excellence. As a leading sponsor of clinical trials, the Cleveland Clinic leverages its multidisciplinary expertise and state-of-the-art facilities to conduct groundbreaking studies aimed at improving patient outcomes across a wide range of medical conditions. With a strong emphasis on patient-centered care, the institution fosters collaboration among researchers, clinicians, and patients to explore new treatments and therapies, contributing significantly to the global body of medical knowledge.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Cleveland, Ohio, United States
Patients applied
Trial Officials
W. H. Wilson Tang, MD
Principal Investigator
The Cleveland Clinic
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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