Complete Mesocolic Excision in Comparison With Conventional Surgery for the Right Colon Cancer

Launched by UNIVERSITY OF TURIN, ITALY · Apr 28, 2021

Keywords

ClinConnect Summary

This clinical trial is looking at a type of surgery called Complete Mesocolic Excision (CME) to see how it compares to conventional surgery for patients with cancer in the right side of the colon. The goal is to find out if CME can improve outcomes for those needing surgery for this type of cancer. The trial is currently recruiting participants, specifically adults aged 65 to 85 who have a confirmed diagnosis of right colon cancer that has not spread to other parts of the body.

To be eligible for this trial, participants need to be in good overall health (graded I-III by the American Society of Anesthesiologists) and must provide informed consent. Certain individuals, such as those over 85 years old, those with obesity (BMI over 30), or those with other specific medical conditions, may not qualify. If you join the study, you will undergo either the CME procedure or the standard surgery and will be monitored closely to understand the effects of each method. This trial could help improve treatment options for future patients with similar conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • American Society of Anesthesiologists(ASA) grade I-III.
• • Right colon cancer (\*The right-sided location of the cancer is defined as the location from the caecum up to the proximal third of the transverse colon), preoperative assessment of tumor stage T2-T4a, any N or T any N+ according to the National Comprehensive Cancer Network(NCCN) clinical practice guidelines in oncology: colon cancer version 2.2015); no distant metastasis.
• • Informed consent
• Exclusion Criteria:
• • Age \> 85 years old.
• • T1, N0
• • T4b, any N
• • BMI \> 30.
• • Metastatic disease (Abdominal and chest CT scan will be mandatory to exclude distant metastasis.)
• • American Society of Anesthesiologists(ASA) grade IV.
• • History of cancer in recent 5 years.
• • Need for Emergency surgery.
• • Infectious disease requiring treatment.
• • Pregnancy.
• • Use of systemic steroids.
• • No history of familial adenomatous polyposis, ulcerative colitis or Crohn's disease.