Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury

Launched by UNIVERSITY OF NORTH CAROLINA, CHAPEL HILL · Apr 30, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how different types of rehabilitation after ACL (anterior cruciate ligament) surgery can affect the risk of developing osteoarthritis in the knee. Researchers want to find out if adding whole body vibration (WBV) or local muscle vibration (LMV) to standard rehabilitation can improve muscle function, walking patterns, and overall knee health. Participants will be divided into three groups: one receiving standard rehab, another with standard rehab plus WBV, and the last with standard rehab plus LMV. They will undergo various assessments at 1, 6, and 12 months after their surgery to see how these different approaches impact their recovery.

To be eligible for this trial, participants should be between 16 and 35 years old and have undergone a primary ACL reconstruction surgery using a specific type of graft. Those who have had previous knee injuries or surgeries, or certain other medical conditions, will not be eligible. Throughout the trial, participants can expect regular check-ins to evaluate their muscle strength, movement patterns, and knee health through tests and MRI scans, helping researchers understand if vibration therapy can enhance rehabilitation outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 16 to 35 years
• • Unilateral, primary ACLR with bone-patellar tendon-bone autograft
• Exclusion Criteria:
• • History of prior ACL injury or revision ACLR
• • History of prior knee surgery
• • Requirement of multiple ligament surgery at time of ACLR
• • Concomitant injuries or surgical procedures at the time of ACLR that would delay early post-operative weight bearing based on surgeon recommendations (e.g. lower extremity fracture, intra-articular fracture, microfracture procedure)
• • Removal of more than 1/3 of the medial or lateral meniscus at the time of ACLR
• • Articular cartilage damage greater than 3A on the International Cartilage Repair Society Criteria at the time of ACLR
• • History of musculoskeletal injury to either leg in the 3 months prior to participation other than primary ACL injury
• • Prior diagnosis of radiographic OA in any joint of the lower extremity
• • History of neurological disorder (e.g. stroke, multiple sclerosis, etc.)
• • Contraindications for MRI (e.g. extreme claustrophobia, cardiac pacemaker, cochlear implant, metal foreign bodies, aneurism clip, etc.)
• • Pregnant or planning to become pregnant